Cardinals vs. Bears prediction, odds, spread, injuries, trends for NFL Week 16

A full betting preview for the Chicago Bears' Week 16 matchup against the Arizona Cardinals.

Dec 10, 2023; Chicago, Illinois, USA;  Chicago Bears quarterback Justin Fields (1) against the
Dec 10, 2023; Chicago, Illinois, USA; Chicago Bears quarterback Justin Fields (1) against the / Jamie Sabau-USA TODAY Sports

After squandering another fourth quarter last week, the Chicago Bears return home on Sunday to play the Arizona Cardinals. The Bears had a 17-7 lead heading into the fourth quarter against the Browns, but allowed Cleveland to score 13 unanswered points.

Chicago will hope to bounce back at home this week, where they've won three straight games. The Cardinals have lost three out of their last four games, including a 16-point loss at home last week to the 49ers.

The Bears are four-point home favorites against the Cardinals. Below, we will break down this Week 16 matchup and give our best bet!

If you are going to bet on this game, make sure to do it with our partner DraftKings! If you sign up below, you will get $150 in bonus bets instantly on your first bet of $5 AND a no sweat single game parlay every day this football season! All you have to do is opt in below!

Cardinals vs. Bears Odds, Spread and Total

Cardinals vs. Bears Betting Trends

  • The Cardinals are 1-5 against the spread (ATS) in their last six games vs. NFC North opponents
  • The UNDER is 5-0 in Arizona’s last five road games
  • Chicago is 4-2 ATS in their last six games
  • The UNDER is 6-1 in the Bears’ last seven games

Cardinals vs. Bears Injury Reports

Cardinals Injury Report

  • Tyreke Smith - LB - Questionable
  • Marquise Brown - WR - Questionable
  • Geoff Swaim - TE - Questionable

Bears Injury Report

  • Equanimeous St. Brown - WR - Questionable
  • Noah Sewell - LB - Questionable
  • Teven Jenkins - OT - Questionable

Cardinals vs. Bears How to Watch

  • Date: Sunday, Dec. 24
  • Game Time: 4:25 p.m. EST
  • Venue: Soldier Field
  • How to Watch (TV): FOX
  • Cardinals Record: 3-11
  • Bears Record: 5-9

Cardinals vs. Bears Key Players to Watch

Arizona Cardinals

James Conner: The veteran running back is coming off a solid rushing performance against the San Francisco 49ers last week. Conner ran for 86 yards and a touchdown on 14 carries. It is the second consecutive game the 28-year-old running back has scored a touchdown. He’ll look to add to his total against the Bears’ defense on Sunday, which has allowed seven rushing touchdowns this season.

Chicago Bears

Justin Fields: Fields didn’t have his best game throwing the ball last week against the Browns, who held him to a 47.5 completion percentage, 166 yards, a touchdown, and two interceptions. The good news for Fields is that he should have better luck against Arizona, which has allowed 219.3 passing yards per game (13th in the NFL) and opposing QBs to complete 69.5% of their passes (second-worst in the NFL).

Cardinals vs. Bears Prediction and Pick

The Bears have found ways to lose multiple games over the last few weeks, which has changed the trajectory of their season. Last week against the Browns, Chicago had a 17-7 lead heading into the fourth quarter. However, the Bears allowed Cleveland to score 13 unanswered points to win the game by three.

Nevertheless, Chicago returns home on Sunday to play Arizona, where they won three straight games. Their defense has played a huge factor in their improved play at home, allowing 12.6 points per game in their last three contests.

The Cardinals’ offense is scoring 20 points per game in their last two road games with Kyler Murray under center. However, Arizona is facing the best run defense in the league, which could force Murray to drop back more and lean on the passing game.

Outside of their 14-point win over the Steelers, the Cardinals have been ripped to shreds by the Rams and 49ers. At the same time, Chicago has played competitive football over the past three weeks. I trust Fields and the Bears’ defense to make plays more than I do Murray and Arizona.

Game odds refresh periodically and are subject to change.